Radioluminescence Microscopy - Single-cell Detection of Radiophamaceuticals

I. Radioluminescence Microscopy (RLM)

Radioluminescence microscopy is capable of quantitatively imaging radiopharmaceutical uptake in single cells. We use the RLM to explore the heterogeneous response of disease cells to various clinical or developmental radiolabeled drugs. 

II. Nuclear Medicine-on-a-chip 

The purpose of Nuclear Medicine-on-a-chip is to understand how the detection limit of PET is affected in response to various therpeutic conditions (e.g., radiation therapy). Combining RLM with microfluidic platforms enable radiopharmaceutical response studies in single cancer cells exposed to various therapy conditions. 

III. Low-light Imaging

As low-light microscopy is sensitive to dim signals, it is suitable for imaging other luminescent modes that are difficult to image using conventional microscopes. Using the low-light microscope, we demonstrated bioluminescence imaging with high temporal resolution.